Senior Tory MP Anne McIntosh has lost her battle against de-selection by local Conservatives.
In a statement, the party said that the Thirsk and Malton Conservative Association had voted not to re-adopt her as their candidate for the next general election.
Miss McIntosh, who has been an MP since 1997, immediately announced that she intended to stand as an independent in the seat which she held at the last election with an 11,281 majority.
Speaking outside Conservative HQ in London where the votes were counted, a defiant Miss McIntosh said: "I do not intend to be thrown aside by a small group.
"It is for my constituents as a whole to dismiss me if they wish to do so."